人类 zona pellucida 的超弹性模型及其对临床实践中剪切模量估计的影响
E Priel1,2, B Mittelman3,4, L Efraim3
1Department of Mechanical Engineering, Shamoon College of Engineering, Beer-Sheva, 84100, Israel. eladp@sce.ac.il.
Scientific reports
|December 29, 2024
概括
人类卵细胞 Zona Pellucida (ZP) 的机械特性可以预测生命力. 新胡金和穆尼-里夫林模型对于从细胞内注射精子 (ICSI) 数据中确定ZP切割模量更为敏感.
科学领域:
- 生物医学工程 生物医学工程
- 生殖医学 生殖医学
- 材料科学 材料科学 材料科学
背景情况:
- 卵细胞的机械性质,特别是 Zona Pellucida (ZP) 的剪切模量,是卵细胞生存能力的潜在指标.
- 以前的研究表明,在注射细胞内精子 (ICSI) 后将ZP剪切模块纳入胚胎移植协议,可能会提高植入率.
研究的目的:
- 评估不同超弹性构成模型在确定卵细胞特异性ZP剪切模量时的灵敏度.
- 研究各种应变能量密度函数 (SEDF) 对ZP剪切模量计算的影响.
主要方法:
- 使用了一种代的卵细胞特异有限元素 (FE) 分析框架.
- 应用了三种不同的超弹性SEDF:新霍金 (NH),穆尼-里夫林 (MR) 和奥格登 (OG) 模型.
- 使用临床ICSI数据和分析模型灵敏度确定ZP剪模.
主要成果:
- 与Ogden (OG) 模型相比,Neo-Hookean (NH) 和Mooney-Rivlin (MR) 模型在提取ZP剪模量方面表现出更高的灵敏度.
- 在ICSI过程中施加的吸气压力对ZP剪切模量识别的准确性有显著的影响.
结论:
- 构成模型的选择对ZP剪切模量确定的准确性产生了重大影响.
- 在ICSI程序中,NH和MR模型为ZP剪切模量评估提供了更可靠的方法.
- 在ICSI期间的吸气压力是影响机械性质分析精度的关键参数.
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