慢性艾滋病毒和艾滋病毒相关的神经认知障碍 (HAND) 中的先天免疫记忆:潜在的机制和临床影响
Zachary Capriotti1,2, Zachary Klase3,4,5
1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA.
Journal of neurovirology
|December 29, 2024
概括
训练有素的免疫力,一种天生的免疫记忆,可能会在接受抗逆转录病毒疗法 (ART) 的艾滋病毒感染者 (PLWH) 中驱动慢性炎症. 这种免疫状态可能会使艾滋病毒并发症恶化,并使治疗策略复杂化.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 抗逆转录病毒疗法 (ART) 改善了艾滋病毒/艾滋病的结果,但使艾滋病毒感染者 (PLWH) 容易患上诸如心血管疾病 (CVD) 和艾滋病毒相关的神经认知障碍 (HAND) 等并发症.
- 慢性炎症和免疫激活与这些并发症有关,并与训练有素的免疫有共同特征.
- 训练有素的免疫是先天的免疫记忆,重新编程免疫细胞以提高炎症反应.
研究的目的:
- 在HIV病变发生过程中审查先天免疫记忆.
- 探索训练免疫在艾滋病毒并发症和治愈策略中的潜在作用.
- 突出在艾滋病毒的背景下对训练免疫的进一步研究的需要.
主要方法:
- 关于先天免疫记忆的文献综述.
- 在HIV病原发生过程中训练免疫的分析.
- 考虑训练免疫对并发病和治愈的影响.
主要成果:
- 训练免疫力,其特点是先天免疫细胞的表观遗传和代谢重编程,是各种疾病中已知的现象.
- 有证据表明,训练有素的免疫力可能会导致ART上的PLWH慢性炎症和免疫激活.
- 这种免疫表型可能会在病毒根除后持续存在,可能会使艾滋病毒治愈工作复杂化.
结论:
- 训练有素的免疫力可能是PLWH慢性炎症和免疫激活的基础,有助于诸如HAND.这样的并发症.
- 训练有素免疫的持久性可能会对艾滋病毒根除和治愈策略构成挑战.
- 对艾滋病毒训练免疫的进一步研究对于开发用于艾滋病毒并发症的新疗法至关重要.
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