从FDG PET/CT的纹理参数来预测伪二的预后值,用于局部晚期直肠癌患者,同时接受新辅助化学或放射治疗
Hyunjong Lee1, Seung Hyup Hyun1, Yong Beom Cho2
1Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul, 06351, Republic of Korea.
与MTV和TLG等标准指标相比,对FDG PET/CT纹理参数的伪实时分析为直肠癌患者提供了更好的预后价值. 这种新的方法确定了整体生存率的独立预测指标.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医学成像分析 医学成像分析
背景情况:
- 对FDG PET/CT的纹理分析提供了与瘤生物学相关的复杂图像参数.
- 现有的参数缺乏明确的含义,需要先进的分析方法.
研究的目的:
- 为预后评估,将伪时间分析应用于FDG PET/CT纹理参数.
- 评估伪素时作为直肠癌的独立预后因素的重要性.
主要方法:
- 从224名直肠癌患者的前neoadjuvant CCRT FDG PET/CT中提取了纹理参数.
- 使用了Phenopath工具来从质地参数中导出伪名词.
- 进行了生存分析,将伪药与临床病理特征和结果相关联.
主要成果:
- 伪药,代谢性瘤体积 (MTV) 和总损伤糖解 (TLG) 与整体存活率有关.
- 伪药物成为一个独立的预后因素 (HR=4.807,p=0.037),表现优于MTV和TLG.
- 伪物质分析将多种不同的代谢纹理参数整合到一个单一的,有意义的指标.
结论:
- 来自FDG PET/CT纹理分析的伪素是局部晚期直肠癌中强大的独立预后指标.
- 与传统的PET参数相比,这种方法在接受三种模式治疗的患者中提供了更高的预后意义.
更多相关视频
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
07:54Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
相关概念视频
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
