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Updated: Jun 4, 2025

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在胚胎发生过程中SLC25A1基因的失活会诱导由p53控制的独特衰老程序

Anna Kasprzyk-Pawelec1, Mingjun Tan1,2, Raneen Rahhal1

  • 1Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, D.C., USA.

Cell death and differentiation
|December 29, 2024
PubMed
概括

在SLC25A1中发生的生殖系突变会导致人类疾病. 鼠标模型显示,Slc25a1缺乏通过p53触发衰老,导致D/L-2-基酸氨酸尿 (D/L-2HGA). 恢复NAD+或清除2HG显示治疗承诺.

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