在结核病治疗中,长期的门诊亲肠道抗菌药物疗法是自给自取的
A Rauch1,2,3, N Köhler4,5,6,7, T T Brehm1,2,8
1Division of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Drugs
|December 29, 2024
概括
自治室门诊关节肠道抗菌疗法 (sOPAT) 是对精选的结核病患者,包括具有耐药菌株的患者,可行的治疗方法. 这种方法表明,当提供适当的基础设施和培训时,并发症风险较低.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 抗微生物药物管理委员会
背景情况:
- 结核病 (TB) 的治疗通常需要长期的静脉注射抗菌药物治疗.
- 耐药结核病菌株需要复杂和延长的治疗方案.
- 门诊亲肠道抗微生物疗法 (OPAT) 为长时间住院提供了替代方案.
研究的目的:
- 在一组结核病患者中,评估自我管理的门诊亲肠道抗菌药物治疗 (sOPAT) 的安全性和临床结果.
- 评估sOPAT对患有多抗药性 (MDR) 结核病和前广泛耐药性 (XDR) 结核病的患者的可行性.
- 在结核病治疗的背景下,识别与sOPAT相关的并发症.
主要方法:
- 在德国临床推中心进行的回顾性观察队列研究.
- 包括2015年1月至2020年12月期间接受sOPAT的患者.
- 从医疗记录中提取数据,用于安全性和结果分析.
主要成果:
- 89名结核病患者,主要是MDR-TB或XDR-TB前期,接受了sOPAT.
- 大多数患者 (69.7%) 成功完成了他们的sOPAT治疗方案.
- 停止治疗的常见原因包括不良药物事件 (13.5%),与港口相关的并发症发生在9.0%的患者.
结论:
- 对于需要长期静脉注射治疗的精选结核病患者来说,sOPAT是一种可行且安全的治疗选择.
- 成功实施sOPAT取决于适当的基础设施和患者培训.
- 这种方法可以减少结核病患者长期住院的负担.
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