在接受化疗的急性髓性白血病患者中,香条纹提取物补充对发烧性中性的作用:一项随机对照研究
Budi Setiawan1, Eko Adhi Pangarsa1, Damai Santosa1
1Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi General Hospital, Semarang, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|December 29, 2024
概括
在接受化疗的急性髓性白血病患者中,Channa striata提取物没有改善中性粒细胞计数或减少发烧性中性粒细胞衰竭. 需要进一步的研究来探索这种严重并发症的替代治疗方法.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 发烧性中性质是接受化疗的血液性恶性瘤患者的关键并发症.
- 一种淡水鱼 (Channa striata) 已被研究其潜在的治疗益处.
研究的目的:
- 评价香条纹提取物在增加中性粒细胞数量和功能的有效性.
- 为了确定 Channa 条纹虫提取物能否在接受化疗的急性骨髓性白血病 (AML) 患者中预防发烧性中性质衰竭.
主要方法:
- 这是一项随机,单盲,受控的研究,涉及32名AML患者.
- 标准的医院营养和香条纹提取物补充剂 (每天6克) 的比较.
- 通过介质蛋白 (IL) - 6和氧化 (NO) 水平评估中性粒细胞的功能.
主要成果:
- 两组之间对中性衰竭的发病或持续时间没有显著差异.
- 与对照组 (43.8%) 相比,在香条纹提取物组 (85.7%) 观察到发烧性中性衰竭的更高发病率.
- 在Channa条纹群体中发现了增加IL-6水平的趋势,但在统计学上并不显著.
结论:
- 香条纹提取物补充剂没有积极影响AML患者的中性衰竭参数或发烧性中性衰竭发病率.
- 提取物没有通过IL-6和NO水平测量来增强中性粒细胞功能.
- 目前的研究结果不支持使用 Channa striata 提取物来治疗 AML 中的化疗诱导的中性质疏松症.
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