阿尔茨海默病患者的完整血清和全身炎症指数:一个病例对照研究
Jéssica A G Tosatti1, Jessica D Pereira1, Cristina M G Loures1
1Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
概括
阿尔茨海默病与促炎状态有关,由较高的中性粒细胞计数和较高的系统性炎症反应指数 (SIRI) 表示. 这些血液标记物可能有助于检测阿尔茨海默病 (AD).
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 是导致痴呆的主要原因,与衰老和慢性炎症有关.
- 炎症可能导致或由AD特征的蛋白质病变 (粉样和积) 导致.
研究的目的:
- 为了调查AD患者的完整血清 (CBC) 和全身炎症指数.
- 为了比较AD患者和认知健康对照之间的这些标志物.
主要方法:
- 研究了61名阿尔茨海默病患者和59名健康对照人群.
- 利用自动化系统进行全血细胞计 (CBC) 分析.
- 采用NIA-AA标准和脑脊液生物标志物用于AD诊断.
主要成果:
- 阿尔茨海默病患者的中性粒细胞数量显著增加,中性粒细胞与淋巴细胞的比例显著增加,系统性炎症反应指数 (SIRI) 显著增加.
- 阿尔茨海默病患者的淋巴细胞和血小板数量显著下降.
- 在对共变量进行调整后,中性粒细胞数和SIRI仍然是AD的显著预测因素.
结论:
- 阿尔茨海默氏症与低级的炎症前驱特征有关.
- 血液免疫细胞的变化有助于AD的系统性炎症指数升高.
- 来自CBC的炎症指数在AD评估中显示出潜在的有用性.
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