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维生素D,免疫功能和动脉样硬化. 我们现在在哪里?

Ailyn Rivero¹, Kent R Wehmeier¹, Michael J Haas¹

¹Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida College of Medicine, Jacksonville, FL 32206.

Nutrition research (New York, N.Y.)

|December 29, 2024

概括

维生素D缺乏与心血管疾病 (CVD) 风险有关. 虽然一些研究表明,维生素D补充对心血管疾病死亡率的益处有限,但其他研究表明,维生素D补充具有潜在的优势,需要进一步研究.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
心血管医学心血管医学

背景情况:

维生素D对于代谢,骨健康和免疫功能至关重要.
维生素D缺乏 (<20 ng/mL) 与心血管疾病 (CVD) 风险增加有关.
心血管疾病是导致死亡的主要原因,由炎症和其他因素,如高血压和糖尿病驱动.

研究的目的:

审查关于维生素D在免疫功能中的作用及其与心血管疾病的关系的证据.
评估维生素D补充剂在预防心血管疾病和降低心血管疾病相关死亡率方面的有效性.

主要方法:

对流行病学研究,随机临床试验和临床前研究进行系统审查和元分析.
对检查维生素D水平与心血管疾病风险和死亡率相关的研究分析.
对预防心血管疾病的维生素D补充剂随机临床试验的评估.

主要成果:

一些元分析表明,维生素D补充剂对缺陷个体的心血管疾病死亡率的影响很小.
精心设计的随机试验表明,维生素D治疗对心血管疾病并发症风险较高的人群的潜在益处.
患者免疫功能的最佳维生素D水平尚不清楚.

结论:

关于维生素D对心血管疾病死亡率的影响的证据是混合的,一些研究表明益处有限,而另一些研究表明潜在的优势.
需要更多的研究来确定免疫功能最佳的维生素D度及其在预防心血管疾病方面的成本效益.
需要进一步研究以澄清维生素D补充剂在控制心血管疾病风险中的作用.

关键词:

动脉样硬化是一种动脉样硬化.冠状动脉疾病是一种冠状动脉疾病.炎症炎症是一种炎症.维生素D 维生素D是一种维生素.

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