新型多功能根管灌剂的生物和化学特性
Nidambur Vasudev Ballal1, Rajkumar Narkedamalli1, Padmaja A Shenoy2
1Department of Conservative Dentistry & Endodontics, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Journal of dentistry
|December 29, 2024
概括
EndoJuiceTM和EDTA有效地去除了涂抹层,而EndoJuiceTM在顶端三分之一中表现出色. 特里顿显示出优越的抗菌活性和组织溶解,但比EndoJuiceTM更有细胞毒性.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 牙科材料科学 牙科材料科学
背景情况:
- 有效的根管灌对于去除涂抹层和消除微生物至关重要.
- 多功能灌解决方案旨在结合清洁,消毒和组织溶解特性.
研究的目的:
- 为了比较多功能根管灌剂 (Triton,EndoJuiceTM,EDTA) 在涂抹层去除,抗菌活性,细胞毒性和组织溶解方面的疗效.
- 评估这些灌剂的安全性和有效性,用于临床内牙治疗.
主要方法:
- 40个单根牙的机械仪器,然后用Triton,EndoJuiceTM,EDTA或盐水灌.
- 通过扫描电子显微镜评估的涂抹层去除.
- 使用殖民地形成单元分析评估的对Enterococcus faecalis生物膜的抗菌活性.
- 在中国仓鼠V79细胞上评估了细胞毒性和基因毒性.
- 在肉上测试了组织溶解的有效性.
主要成果:
- 与Triton相比,EndoJuiceTM和EDTA表现出更好的涂抹层去除,特别是在顶部三分之一.
- 特里顿和甲在降低Enterococcus faecalis数量方面表现出类似的有效性.
- 与Triton相比,EndoJuiceTM的细胞毒性和基因毒性较低.
- 低化呈现出最高的组织溶解,其次是Triton和EndoJuiceTM.
结论:
- EndoJuiceTM提供了有利的特征,具有降低的毒性和增强的涂抹层去除.
- 特里顿提供更强大的抗微生物和组织溶解能力,但具有更高的细胞毒性.
- 对灌剂的全面评估对于在根管治疗中安全有效的临床应用至关重要.
相关概念视频
Chemical Agents for Microbial Control
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Local Anesthetics: Common Agents and Their Applications
403
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
403
Hand hygiene
3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.1K
Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K


