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细胞癌与静脉瘤血栓具有对肺部的偏好

Reza Nabavizadeh¹, Rodrigo Rodrigues Pessoa¹, John C Cheville²

¹Department of Urology, Mayo Clinic, Rochester, MN.

|December 29, 2024

概括

静脉瘤血栓 (VTT) 在清细胞细胞癌 (ccRCC) 患者中显著增加了肺转移的风险. 在VTT病例中的肺栓塞进一步提高了手术后的风险.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
医学研究医学研究

背景情况:

清细胞细胞癌 (ccRCC) 是癌最常见的亚型.
静脉瘤血栓 (VTT) 是ccRCC中已知的预后因素.
在VTT和肺转移风险之间的关系需要进一步阐明.

研究的目的:

研究cccRCC患者的VTT与肺转移风险之间的关联.
确定VTT是否是ccRCC中肺转移的独立预测因素.
评估VTT对同步和超时肺转移的影响.

主要方法:

对ccRCC患者的激进腎切除注册 (1970-2019) 的回顾性分析.
考克斯的比例危险回归模型被用来评估这种关联.
对与ccRCC进展相关的因素进行了统计调整.

主要成果:

在3410名ccRCC患者中,有30%患有VTT.
VTT与同步肺转移 (20%与7%相比) 的可能性更高有关.
VTT仍然与甲时慢性肺转移的风险增加有关 (HR 1.31).
在VTT患者的肺栓塞 (PE) 增加了腎切除術后肺轉移的風險 (HR 2.31).

结论:

在ccRCC患者中,VTT与肺转移的增加显著相关,在呈现和切术后.
在VTT患者中存在PE进一步增加了肺转移的风险.
有VTT的ccRCC显示出对肺转移的倾向.

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