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在人类饮食暴露研究中优先考虑相关的多甲 (PCN) 同源物

Alwyn R Fernandes¹, Alexander Schächtele², Rainer Malisch²

¹School of Environmental Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.

|December 29, 2024

概括

饮食摄入是多甲 (PCN) 对人类的主要暴露途径. 这项研究提出了20个关键的PCN同源物用于食品监测,以帮助评估毒性等价性 (TEQ).

科学领域:

环境化学环境化学
毒理学毒理学毒理学
食品安全食品安全

背景情况:

多甲 (PCN) 是类似于二氧化的污染物,通过饮食摄入作为人类的主要暴露途径.
从历史生产和正在进行的燃烧来源的全球再分配有助于PCN在食品中的无处不在.
参考标准的进步允许更准确地检测各种PCN同源.

研究的目的:

建议对20种多甲 (PCN) 同源进行初步选择,用于对食品的监测.
为了提供一种可靠的指标,对食品中总体的二氧化类毒性等效 (TEQ).
评估所选的同源对人类组织暴露的代表性.

主要方法:

将食物发生率数据与相对强度 (REP) 值结合起来.
分析食品和人体组织中PCN同源的现有数据.
利用新可用的PCN参考标准来提高准确性.

主要成果:

建议在食品监测中初步选择20种PCN同源.
这种选择预计将准确地反映食品中的整体PCN TEQ,特别是在工业化地区.
选择的同源似乎代表了在人体组织中发现的PCN TEQ.

结论:

拟议的同源选择为通过饮食评估PCN暴露提供了可靠的方法.
未来的研究将通过扩展标准来完善对PCN发生率和毒性的理解.
持续的毒理学研究将有助于进一步完善对综合风险评估的同源选择.

关键词:

亚利碳化合物受体 (AhR) 是一种与二氧化物类似的毒性食物污染食物污染在PCN的同源模式下,PCN的同源模式.斯德哥尔摩公约 POPs 污染物

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