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与微生物群相关的代谢物与COVID-19患者的严重程度相关

Xiao-Sen Wang¹, Jing-Yu Wang², Fei Yu³

¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Hepatobiliary & pancreatic diseases international : HBPD INT

|December 29, 2024

概括

在COVID-19患者中,改变的微生物代谢物与疾病严重程度和器官损伤相关. 这些变化在出院后仍然存在,这表明肠道微生物群是严重的COVID-19的潜在治疗目标.

科学领域:

微生物组研究的研究.
代谢学代谢学代谢学
传染性疾病传染性疾病.

背景情况:

冠状病毒疾病2019 (COVID-19) 对严重病例的治疗选择有限.
在严重的COVID-19中观察到改变的肠道微生物群,但微生物代谢物的作用尚不清楚.
缺乏关于COVID-19患者微生物代谢物的全面数据.

研究的目的:

为了研究COVID-19患者血清微生物代谢物的变化.
为了将这些代谢物变化与疾病严重程度和器官损伤相关联.
评估COVID-19急性和恢复阶段的代谢物水平.

主要方法:

确定了153种血清微生物代谢物.
与72名COVID-19患者 (入院和出院1个月后) 和133名健康对照进行了比较.
评估COVID-19不同阶段和严重程度的代谢物变化.

主要成果:

在COVID-19患者和对照人群中,有13种不同的微生物代谢物存在差异.
改变的代谢物包括托,胆汁酸,脂肪酸,氨基酸,维生素和含的化合物.
与器官损伤和炎症相关的代谢物中断;水平在出院后一个月保持异常.
两种核心微生物代谢物被确定为COVID-19严重程度的关键指标.

结论:

微生物代谢物在COVID-19的急性和恢复阶段发生变化,与疾病严重程度相关.
肠道微生物群在COVID-19的进展中发挥着重要作用.
这些发现突出了严重的COVID-19潜在的治疗微生物点.

关键词:

新冠病毒疾病2019年疾病严重程度疾病严重程度我们的肠道微生物群.代谢学代谢学代谢学

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