基于纳米粒子和微粒子的系统,用于增强口服胰岛素的输送:系统性审查和元分析
Carlos E Romero-Carmona1, Juan I Chávez-Corona1,2, Enrique Lima3
1Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de Mexico, Mexico.
Journal of nanobiotechnology
|December 29, 2024
概括
使用纳米粒子载体的口服胰岛素输送为糖尿病 (DM) 提供了注射的非侵入性替代方案. 一项元分析发现,30 IU封装胰岛素有效降低血糖,其最佳颗粒特征对疗效至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 制药科学 制药科学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病 (DM) 患病率在全球范围内不断增加,需要改进治疗策略.
- 目前的皮下胰岛素注射存在一些局限性,包括副作用和患者不良坚持.
- 通过纳米粒子载体输送口服胰岛素提供了一个非侵入性的,方便的替代方案,有可能改善血糖控制.
研究的目的:
- 系统地审查和对基于纳米和微粒的口服胰岛素输送系统的现有数据进行元分析.
- 确定影响口服胰岛素在治疗糖尿病中的有效性的关键配方参数.
- 为开发创新的口服胰岛素配方提供见解.
主要方法:
- 85篇相关科学文章的系统审查和元分析.
- 分析胰岛素剂量,封装效率,颗粒大小和多分散性指数.
- 对辅助剂影响的评估,重点是基托.
主要成果:
- 胰岛素剂量在广泛范围 (1-120 IU) 中没有与降低葡萄糖的直接相关性.
- 与对照组相比,30 IU封装猪胰岛素剂量显示出显著的低血糖效应.
- 最佳疗效与高封装度 (~90%),颗粒大小 (200-400 nm) 和低多分散度指数 (0.086-0.3) 相关.
结论:
- 通过纳米和微粒输送口服胰岛素是糖尿病管理的一个有前途的策略.
- 特定的配方参数 (封装,颗粒大小,PDI) 对于实现治疗疗效至关重要.
- 由于其生物相容性和形成稳定矩阵的能力,奇托是一种有利的辅助剂,尽管需要进一步的临床前验证.
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