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相关概念视频

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

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相关实验视频

Updated: May 26, 2026

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

CCN3:哺乳期的骨增强剂.

Nathan Xu1, Kyle Yang1, Mengjie Wang2,3

  • 1USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, USA.

Cell & bioscience
|December 29, 2024
PubMed
概括
此摘要是机器生成的。

一个新发现的脑骨轴显示,来自特定神经元的细胞通信网络因子3 (CCN3) 支持哺乳期母亲的骨健康. 这种激素在哺乳期间对骨形成和后代存活至关重要.

关键词:
在ARHERα/Kiss1神经元中.骨形成 骨的形成大脑 - 乳房 - 骨头轴CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3 CCN3哺乳期 哺乳期 是一个

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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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相关实验视频

Last Updated: May 26, 2026

Bone Conditioned Medium: Preparation and Bioassay
07:18

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

科学领域:

  • 内分泌学 在内分泌学.
  • 神经科学是一个神经科学.
  • 骨生物学 骨生物学

背景情况:

  • 哺乳动物的繁殖需要通过母乳从母亲向后代传递大量的.
  • 哺乳期涉及一个复杂的大脑-乳房-骨电路调节激素,摄入量和骨代谢.
  • 传统上,由甲状腺激素相关蛋白和低雌激素驱动的骨质再吸收被认为是牛奶的主要来源.

研究的目的:

  • 调查哺乳期调节母亲骨的新机制.
  • 在大脑骨轴内识别新的信号通路,控制护理期间的平衡和骨形成.
  • 阐明特定神经元因子在支持骨健康和后代存活中的作用.

主要方法:

  • 准生物体实验 准生物体实验
  • 在体内微型计算机断层扫描 (μCT)
  • 骨移植检测试验 骨移植检测
  • 细胞培养和分化研究研究.
  • 鼠标遗传模型的模型
  • 药理干预措施 药理干预措施
  • 肝脏病毒转导 肝脏病毒转导
  • 测序分析分析的测序分析.

主要成果:

  • 细胞通信网络因子3 (CCN3),源自ARHERα/Kiss1神经元,作为一种骨质激素.
  • 这些神经元中的CCN3表达是乳房特异性的,对骨维护至关重要.
  • 在年轻和老年小鼠中,CCN3促进了骨干细胞活性,骨重塑和骨折修复.
  • 哺乳期母亲中CCN3的抑制导致严重的骨质损失和后代存活率受损.

结论:

  • 已经确定了一种新型的脑骨轴,涉及ARHERα/Kiss1神经元中的乳房特异性CCN3表达.
  • 这种CCN3介导的途径对于维持母体骨完整性和确保哺乳期后代的生存能力至关重要.
  • 这一发现为支持哺乳动物繁殖和骨健康的进化适应提供了新的见解.