我们如何定义从新生儿到青少年的正常肠道频率? :贝叶斯的元分析
Sachith Munasinghe1, Supun Manathunga2, Wathsala Hathagoda1,3
1Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Journal of pediatric gastroenterology and nutrition
|December 30, 2024
概括
这项研究分析了0-18岁健康儿童的肠道频率. 年幼的孩子,像新生儿一样,比较年长的孩子更频繁的排便.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 发展生物学 发展生物学
背景情况:
- 排便障碍在儿童中很常见.
- 肠道频率是诊断这些疾病的关键指标.
研究的目的:
- 为从出生到青春期的健康儿童建立正常的肠道排便频率.
- 提供临床使用的参考值,用于识别儿科排便障碍.
主要方法:
- 在主要数据库 (MEDLINE,SCOPUS,EMBASE,Cochrane,Web of Science) 进行了全面的文献搜索,截至2024年2月.
- 贝叶斯分布建模与反变量权衡被用来汇集来自17项涉及22698名儿童的研究的数据.
- 进行了子组分析和元回归,使用修改后的纽卡斯尔-太华尺度评估研究质量.
主要成果:
- 确定了各种年龄组的平均肠道频率:新生儿 (3.24),1-6个月 (1.99),6-12个月 (1.66),1-2年 (1.53),2-5年 (1.15),超过5年的 (1.02).
- 肠道频率分布的差异随着年龄的增加而减少.
- 研究之间的异质性几乎以正常分布分布.
结论:
- 这种贝叶斯元分析证实,儿童的肠道排便频率随着年龄的增长而下降.
- 建立的特定年龄的正常肠道频率可以帮助临床医生区分健康的肠道习惯和儿科排便障碍.
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