接种BNT162b2COVID-19疫苗后的先天免疫反应与反应性相关
Catharina E van Ewijk1,2, Sara Suárez Hernández1, Ronald H J Jacobi1
1Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Vaccine: X
|December 30, 2024
概括
天生的免疫反应强度与COVID-19疫苗的副作用相关. 较高的先天反应性增加了BNT162b2疫苗第一剂后中度症状的可能性,但没有影响抗体水平.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 天生的免疫系统在适应性免疫发育和疫苗反应性方面发挥着作用.
- 了解天生的反应能力和疫苗副作用之间的联系对于疫苗开发至关重要.
研究的目的:
- 为了研究先天免疫反应,疫苗反应性和第一次BNT162b2 (Pfizer-BioNTech) COVID-19疫苗接种后的抗体反应之间的关联.
- 探索先天免疫反应中的个体差异如何影响即时副作用和长期抗体产生.
主要方法:
- 146名健康的荷兰人 (12-59岁) 接种了第一个BNT162b2疫苗.
- 每天通过问卷监测反应性.
- 测量了细胞因子和化学因子水平,以评估先天的反应能力.
- 在28日测量了S1和RBD抗体度的峰值.
主要成果:
- 85%的参与者报告了局部或全身症状,54%的人出现了中度症状.
- 在接种疫苗后检测到更高水平的促炎媒介.
- 具有高先天性免疫反应的个体出现中度症状的几率明显更高 (OR 6.0).
- 在28天的先天反应或症状严重程度和抗体度之间没有发现任何联系.
结论:
- 天生的免疫反应的强度与COVID-19疫苗接种后的反应性严重程度有关.
- 需要进一步的研究来澄清疫苗反应性和免疫性之间的关系.
更多相关视频
相关概念视频
Vaccinations
42.9K
Overview
42.9K
Cross-reactivity
30.9K
Overview
30.9K
Antigens Involved in Adaptive Immunity
320
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
320
B Cell Activation and Differentiation
1.2K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.2K
Immunological Memory
406
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
406
Immune Response Against Viral Pathogens
443
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
443


