长期存活率和食道状细胞癌的危险因素:卡普兰-梅尔和科克斯回归研究
Zheng-Ting Ren1, Mei Kang1, Li-Yang Zhu1
1Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
World journal of gastrointestinal surgery
|December 30, 2024
概括
高体重指数,围神经侵入和吸烟会对食道状细胞癌的存活率产生负面影响. 在中部或下部胸部区域的瘤位置为这些患者提供了更好的预后.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症预后 癌症预后
背景情况:
- 全球食道癌 (EC) 发病率仍然很高,治疗效率不令人满意.
- 改善EC患者的长期存活率和个性化治疗是关键的未满足需求.
- 食道状细胞癌 (ESCC) 需要进一步调查预后因素.
研究的目的:
- 分析食道状细胞癌 (ESCC) 的生存预后.
- 确定影响ESCC患者生存的影响因素.
- 为临床治疗策略提供个性化的见解.
主要方法:
- 来自115名pT3N0M0ESCC患者的临床数据的回顾性分析,这些患者接受了彻底手术治疗.
- 卡普兰-梅尔方法评估1年,3年和5年的整体存活率 (OS) 和中位生存时间.
- 考克斯的比例危险回归模型用于评估风险因素及其危险比率 (HR).
主要成果:
- 一年,3年和5年的生存率分别为85.22%,50.43%和37.48%;中位数的生存率为37.00个月.
- 高体重指数 (BMI),阳性围神经侵袭 (PNI) 和吸烟是不良预后 (HRs > 1) 的独立风险因素.
- 与上胸部部位相比,中和下胸部瘤位置与更好的预后有关 (HRs < 1).
结论:
- 体重指数,瘤位置,PNI和吸烟显著影响ESCC患者的预后.
- 鉴定了T3N0M0ESCC患者进行激进手术的预后风险因素.
- 结果为优化临床治疗和改善患者治疗结果提供了个性化的见解.
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