Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

721
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
721
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

444
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
444

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Sensory-selective Sciatic Nerve Block with 2',6' Pipecolylxylidine in an Ovine Model.

Anesthesiology·2026
Same author

The Challenges and Promise of AI for Clinical Documentation in Pediatric Inpatient Care.

Hospital pediatrics·2026
Same author

Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide: Erratum.

Anesthesiology·2026
Same author

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice.

Science translational medicine·2026
Same author

Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy.

Nature communications·2026
Same author

Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2',6'-Pipecoloxylidide.

Angewandte Chemie (International ed. in English)·2026

相关实验视频

Updated: Apr 12, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

15.9K

在静脉形缺陷中依赖尺寸的纳米粒子积累.

Kathleen Cullion1,2, Claire A Ostertag-Hill1,3, Weimin Tang1,2

  • 1Laboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Journal of vascular anomalies
|December 30, 2024
PubMed
概括

较小的纳米粒子 (NP) 通过增强的透和保留 (EPR) 效应在静脉形 (VMs) 中呈现增强的积累. 这项研究确定了VM药物输送的最佳NP大小,提高了治疗疗效和降低毒性.

关键词:
药物输送是药物输送的过程.增强了透和保留的功能.纳米颗粒是一种纳米粒子.静脉形 静脉形 静脉形

更多相关视频

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.2K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.3K

相关实验视频

Last Updated: Apr 12, 2026

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
14:10

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

15.9K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.2K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.3K

科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术
  • 血管生物学 血管生物学

背景情况:

  • 目前用于静脉形 (VMs) 的治疗包括具有毒性副作用的全身药物或具有高风险的复杂程序.
  • 纳米颗粒 (NP) 提供了一种潜在的策略,可以改善向VMs的药物输送,通过增强透和保留 (EPR) 效应提高疗效并减少全身毒性.
  • 在VM中NP大小对EPR的影响在很大程度上仍未被探索.

研究的目的:

  • 通过增强透和保留 (EPR) 效应,研究纳米粒子大小对静脉形 (VMs) 内积累的影响.
  • 确定在虚拟机中被动积累的最佳纳米粒子大小,为未来的治疗策略提供信息.

主要方法:

  • 通过使用含有常见VM相关突变的特定内皮细胞建立了皮下VMs的小鼠模型.
  • 多种尺寸 (20,50,80,180 nm) 的空心纳米粒子 (NP) 被涂上聚乙烯糖醇 (PEG) 并与光体结合,被系统地施用.
  • 在VM和器官内NP积累量化使用共聚焦显微镜和体内成像系统.

主要成果:

  • PEGylated空心二氧化NP表现出水力动力直径在31.6nm到232nm之间.
  • 与较大的NP相比,较小的NP在虚拟机中显示出明显更大的积累.
  • 具体来说,20纳米NP的积累比50纳米NP的积累大2倍,比80纳米以上NP的积累大6倍 (P < .01).

结论:

  • 这项研究确定20纳米是通过EPR效应在静脉形中纳米粒子积累的最佳尺寸.
  • 这些发现为开发尺寸优化纳米粒子用于向VM治疗提供了关键的基础.
  • 优化NP大小可以提高治疗疗效,并最大限度地减少VM管理中的非目标毒性.