茶叶和树叶提取物对抗多药耐药微生物的抗菌活性
Shah Rucksana Akhter Urme1, Syeda Fahmida Ahmed2, Md Abdus Shukur Imran3
1Department of Biochemistry & Chemistry, Sylhet Agricultural University, Sylhet, Bangladesh.
BioMed research international
|December 30, 2024
概括
来自孟加拉国的茶叶和叶提取物显示出显著的抗微生物和抗氧化特性. 与抗生素的协同作用为对抗多药耐药病原体提供了一个有希望的途径.
科学领域:
- 植物化学 植物化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多药耐药 (MDR) 菌株对公共卫生构成重大挑战,需要发现新型抗菌剂.
- 植物衍生的二次代谢物,包括类,类,黄类和类,已显示出对抗耐药性病原体的潜力.
研究的目的:
- 为了研究茶叶 (Camellia sinensis) 和木 (Aquilaria malaccensis) 叶片的植物化学成分和抗菌活性.
- 评估这些植物提取物与现有的抗生素对抗MDR病原体的协同作用.
主要方法:
- 六种叶子提取物 (三种茶品种:BT-6,BT-7,BT-8;绿茶,黑茶和阿加木叶) 的植物化学概况 (质量和数量).
- 抗微生物活性测定针对选择的MDR细菌和真菌.
- 通过将植物提取物与商业抗生素相结合来评估协同作用.
主要成果:
- 绿茶具有较高的总含量 (TPC) 和总黄含量 (TFC).
- 叶子提取物显示出显著的抗菌活性,绿茶显示出对克莱布西拉肺炎和BT-8对Pseudomonas aeruginosa的22.0毫米抑制区域.
- 结合BT-8提取物与ceftiofur,以及绿茶与 gentamicin/erythromycin,显示出对大肠杆菌和 Mucor circinelloides 的显著协同效应.
结论:
- 来自孟加拉国的茶叶和叶含有丰富的生物活性化合物,具有强大的抗氧化,抗菌和抗真菌特性.
- 这些植物提取物作为开发新抗菌药物和提高现有抗生素疗效的天然来源具有前途.
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