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恶性瘤的风险和多发性硬化症疾病修饰疗法的使用:在多中心研究中探索DMT的作用
Mohammed Bayounis1,2, Mohammed Bin Mahfooz1,2, Mohammed Assiri1,2
1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Frontiers in neurology
|December 30, 2024
概括
这项研究发现了疾病修饰疗法 (DMT) 与多发性硬化症 (MS) 患者的癌症之间的潜在联系. 对于接受DMT的MS患者,建议进行警性癌症查.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 有关疾病修饰疗法 (DMT) 和多发性硬化症 (MS) 患者的恶性瘤风险存在担忧,因为它们具有免疫抑制性.
- 相互矛盾的证据需要进一步研究DMT与MS癌症之间的关系.
- 这项研究调查了在沙特阿拉伯接受DMT的MS患者癌症的发生情况.
研究的目的:
- 分析DMTs治疗的MS患者的恶性瘤病例.
- 确定DMT的MS患者癌症相关的风险因素,包括人口统计数据,残疾分数和治疗细节.
- 为高风险多发性硬化症患者提供基于证据的癌症查方案.
主要方法:
- 从2015年6月到2023年12月,在沙特阿拉伯的两个三级医疗中心,对860名多发性硬化症患者的医疗记录进行了回顾性审查.
- 数据收集包括人口统计,MS亚型,DMT使用和癌症诊断.
- 从1976年2月到2024年5月的综合文献综述提供了背景.
主要成果:
- 在860名多发性硬化患者中,10名 (1.16%) 患有恶性瘤.
- 恶性瘤更常见于女性 (80%),平均年龄为50.9岁.
- 常见的DMT包括干扰素β和ocrelizumab;常见的癌症是妇科,乳腺,甲状腺和鼻,60%的诊断是在晚期.
结论:
- 这一系列病例表明DMT与MS患者的恶性瘤之间存在潜在联系,需要进一步调查.
- 这些发现强调了癌症查和患者教育在MS治疗中的重要性.
- 需要进一步进行大规模的纵向研究,以确定因果关系,并完善DMT使用的临床指南.
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