相关实验视频

Updated: Jun 4, 2025

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

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流体的流动和粉样蛋白的运输和聚合在大脑的间歇空间间的空间

Antonio Iorio1, Simone Melchionna2,3, Philippe Derreumaux1,4

  • 1Université Paris Cité, CNRS, Laboratoire de Biochimie  Théorique, 13 rue Pierre et Marie Curie, Paris 75005, France.

PNAS nexus
|December 30, 2024
PubMed
概括

大脑废物清除依赖于粉样β蛋白的扩散和较大的聚合物的流体流动. 水力动力相互作用增强蛋白质聚合,影响阿尔茨海默病的进展和治疗策略.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.格子 博尔茨曼 格子分子动力学分子动力学氨基化物 氨基化物大脑间歇空间 间歇空间

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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