脑皮层变化在头骨突症:一个系统的审查
Michail Palaios1, Christos Rapanos1, Ioannis Kapsokavadis1
1Department of Anatomy, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Cureus
|December 30, 2024
概括
这篇综述考察了脑皮层在骨突症中的变化,发现综合征和非综合征形式都会影响大脑结构和连接性. 目前的数据无法明确解释头骨变形是否导致大脑变化或反之.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 头骨突症涉及到头骨的过早融合,影响头骨的形状.
- 大脑皮层的变化,包括体积,尺寸和结构的变化,在骨突症中被观察到.
- 综合征和非综合征形式的关突症都与明显的皮质异常有关.
研究的目的:
- 系统地审查和综合当前关于脑皮层变化在骨突症的文献.
- 调查综合征和非综合征性骨突症中皮质体积,大小和结构 (例如连接性) 的变化.
- 探索现有的关于骨突和皮层发育之间的关系理论.
主要方法:
- 在PubMed数据库的系统文献搜索中,使用与大脑皮层和关节突变相关的特定关键词.
- 包含和排除标准适用于过检索的文章.
- 使用解剖学质量评估 (AQUA) 工具对包含的出版物进行质量评估.
主要成果:
- 综合性关节结症与叶/额叶皮层异常,皮层表面积变化和简化的旋转模式有关.
- 非综合征性关节结症与神经元连接的改变,灰质体积和西尔维亚裂体积有关.
- 关于大脑变化的原因,有两个主要理论 (变形与变形) 存在,但目前的数据不足以解决这一争论.
结论:
- 头骨突导致显著的大脑皮层变化,不同类型的综合征和非综合征.
- 头骨形和大脑形之间的病因关系尚不清楚.
- 治疗策略,主要是手术,正在与新兴的再生医学方法一起发展.
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