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弗卢纳瑞与普罗普兰诺洛尔在预防儿科偏头痛:一个开放式随机试验

N D Vaswani¹, Preet Lamba², Vandana Arya¹

¹Pediatrics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, IND.

|December 30, 2024

概括

弗卢纳瑞和普拉诺洛尔在预防儿科偏头痛方面表现出类似的疗效和安全性. 这两种药物都有效地减少了儿童的头痛日和残疾,具有相似的轻微副作用.

科学领域:

神经学神经学
儿科儿科儿科
药理学药理学是指药理学的学科.

背景情况:

儿科偏头痛严重影响儿童的日常生活,并导致残疾.
在儿科偏头痛中使用预防性药物需要进一步澄清.

研究的目的:

为了比较flunarizine与propranolol在儿科偏头痛预防中的疗效和安全性.
为了评估儿童的头痛频率和残疾的减少治疗用弗隆纳或普拉诺.

主要方法:

一项开放的随机试验,涉及40名患有偏头痛的5至14岁儿童.
患者在12周的时间内接受了弗卢纳瑞 (每天5-10毫克) 或罗 (每天1毫克/公斤) 治疗.
结果包括头痛日减少≥50%,儿童偏头痛残疾评估 (PedMIDAS) 评分的变化以及不良影响.

主要成果:

50%的弗卢纳瑞辛组和55%的普拉诺洛尔组 (p=0.752) 观察到头痛日减少≥50%.
在头痛相关残疾 (PedMIDAS分数变化) 或头痛日减少方面,没有发现群体之间的显著差异.
轻微的不良反应是可比的,在任何一组中都没有报告严重的不良事件.

结论:

弗卢纳瑞在预防儿科偏头痛治疗中与普罗普兰诺洛尔一样有效.
弗卢纳瑞和普拉诺洛尔都是治疗儿童偏头痛的耐受性良好和安全的选择.

关键词:

孩子们的孩子们的孩子们的孩子们.弗卢纳里津 (Flunarizine) 是一种药物.儿科偏头痛儿童偏头痛佩德米达斯是什么意思这种药物是propranolol.

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