喉酸反流发作和质子抑制剂治疗的有效性之间的联系
Yen-Yang Chen1, Chen-Chi Wang2,3,4, Chun-Yi Chuang5,6
1Division of Gastroenterology, Taichung Veterans General Hospital, Taichung 402, Taiwan.
喉酸反流 (PAR) 情节单独可以预测质子抑制剂 (PPI) 治疗喉酸反流 (LPR) 的疗效. 这一发现凸显了在LPR诊断中监测下喉逆流的重要性.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 逆流性疾病是一种反流性疾病.
背景情况:
- 由于重叠的症状和不清楚的质子抑制剂 (PPI) 响应的预测因素,诊断喉回流 (LPR) 是一个挑战.
- 反流监测技术,如 (pH) 传感器的双潜力和多通道内阻抗-pH (MII-pH),为LPR诊断提供了潜在的改进.
- 涉及腹酸反流 (PAR) 和过度食道酸反流 (EAR) 的复合pH参数在预测PPI疗效方面表现有希望.
研究的目的:
- 调查酸逆流 (PAR) 情节是否能预测疑似喉逆流 (LPR) 患者对质子抑制剂 (PPI) 治疗的积极反应.
主要方法:
- 从台湾三所三级医疗中心的耳鼻喉科诊所招募疑似LPR患者.
- 使用3pH传感器或下MII-pH导管进行24小时食道液pH测试,然后服用12周的埃索梅普拉 (40毫克每天两次).
- 根据pH值结果将患者分为四组 (单独PAR,单独EAR,均为pH阳性,均为pH阴性),主要结局是喉症状减少≥50%.
主要成果:
- 在完成治疗的190名患者中,89名 (47%) 对PPI治疗有反应. 仅在PAR组 (73%) 的反应率最高.
- 多变量分析表明,与PAR单独,EAR单独和两个pH阳性的参与者相比,与两个pH负组相比,对PPI治疗的反应明显更有可能 (分别增加7.4倍,4.2倍和3.4倍的可能性).
- 使用≥1个PAR情节定义的二次分析显示了不那么强大的结果,强调了≥2个PAR情节值的意义.
结论:
- 单独的基线喉酸逆流 (PAR) 发作与喉逆流 (LPR) 患者的质子抑制剂 (PPI) 反应相关.
- 这一发现表明,监测喉逆流的重要性,即使在没有明确的喉逆流预测因素的情况下也是如此.
- 这项研究强调了PAR发作作为预测PPI治疗在LPR管理中的成功生物标志物的潜在实用性.
更多相关视频
08:25Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver
Published on: August 27, 2021
10:18Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells
Published on: June 13, 2019
相关概念视频
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...
