在患有侵蚀性胃炎的患者中,rebamipide/nizatidine的有效性和安全性:一个随机的,多中心的,第四阶段研究
Donghoon Kang1, Myung-Gyu Choi2, Ki-Nam Shim3
1Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, South Korea.
World journal of gastroenterology
|December 30, 2024
概括
这项研究发现,结合雷巴米皮德和尼扎提丁与单独的尼扎提丁相比,可以显著提高侵蚀性胃炎的愈合率. 组合疗法在管理粘膜侵蚀方面表现出卓越的疗效,没有任何不良事件.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 雷巴米皮德 (粘膜保护剂) 和尼扎提丁 (抑制酸性) 是标准的胃炎治疗方法.
- 这些药物的个人使用在胃炎管理中很常见.
研究的目的:
- 为了比较rebamipide/nizatidine联合治疗与nizatidine单一治疗的疗效.
- 评估内镜确认侵蚀性胃炎患者的治疗结果.
主要方法:
- 一个开放的,多中心的,随机的第四阶段临床试验.
- 260名患有侵蚀性胃炎的患者被随机分为两组:组合治疗或尼扎提丁单一治疗2周.
- 通过侵蚀改善率,治愈率和症状改善来评估有效性.
主要成果:
- 雷巴米皮德/尼扎提丁组合显示了统计学上显著的更高的侵蚀改善率 (62.0%) 与单独的尼扎提丁 (49.2%) (P=0.046).
- 这两种治疗都有效地治愈了侵蚀/,改善了出血,红血和胃肠道症状,没有显著的群体间差异.
- 改善侵蚀愈合在结合组的胃炎症状患者中更为明显 (63.0%对49.5%,P=0.046).
- 在这两组中都没有报告与药物相关的不良事件.
结论:
- 雷巴米皮德/尼扎提丁组合治疗对于治疗侵蚀性胃炎是有效的.
- 结合疗法提供了一种优越的方法来改善粘膜侵蚀愈合与尼扎提丁单一治疗相比.
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