固体自纳米乳化系统和表面涂层微球的比较:改善尼克洛萨米德的口服生物可用性
Kyungho Baek1, Mi Ran Woo2, Fakhar Ud Din3
1Department of Pharmaceutical Engineering, Dankook University, Cheonan, South Korea.
International journal of nanomedicine
|December 30, 2024
概括
一种新型的固体自纳米乳化药物递送系统 (SNEDDS) 显著提高了尼克洛萨米德的可溶性和口服生物利用性. 这种配方对尼古洛萨米德的重新用途充满希望.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 提高难溶药物的口服生物利用率是制药开发中的一个重大挑战.
- 尼克洛萨米德是一种杀虫剂药物,具有重新利用的潜力,但其口服生物利用性较低.
研究的目的:
- 开发和评估一种固体的自纳米乳化药物递送系统 (SNEDDS),以提高尼古拉胺的口服生物可用性.
- 为了比较固体SNEDDS与表面涂层微球的疗效,用于尼古拉胺的输送.
主要方法:
- 液体SNEDDS使用玉米油,Cremophor RH40和Tween 80优化了液滴大小.
- 尼克洛萨米德被纳入液体SNEDDS,并用酸喷雾干燥,形成固体SNEDDS.
- 使用各种分析技术评估了物理化学性质,可溶性,溶解性和口服生物利用性.
主要成果:
- 固体SNEDDS成功地将尼克洛萨米德转化为无形状态,显著增加了其溶解度 (约. 这是2500倍).
- 尼克洛萨米德的口服生物可用性显著提高 (大约为1. 10倍),使用固体SNEDDS配方.
- 固体SNEDDS与表面涂层微球和单独的尼古洛萨米德相比,表现优越.
结论:
- 开发的固体SNEDDS配方是改善尼克洛萨米德口服的有希望的方法.
- 这种配方可以通过提高尼古拉胺的生物可用性来促进尼古拉胺的重新用途.
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