随着年龄的增长,大脑信号变得不那么集成,更加分离
Rostam M Razban1, Botond B Antal2,3, Ken A Dill1,4,5
1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, USA.
Network neuroscience (Cambridge, Mass.)
|December 30, 2024
概括
随着年龄的增长,大脑活动显示集成减少和分离增加. 在功能性MRI数据中观察到的这种转变反映了区域连接的削弱,而不是大脑结构的变化.
科学领域:
- 神经科学是一个神经科学.
- 物理 物理学 物理
- 医疗成像医学成像
背景情况:
- 整合分离框架简化了大脑动态,将其分为全球 (整合) 和本地 (分离) 信号状态.
- 定义这些大脑状态缺乏标准化的方法,阻碍了一致的分析.
- 来自物理学的Ising模型为定义有序 (整合) 和无序 (分离) 状态提供了一个框架.
研究的目的:
- 通过Ising模型量化定义和计算大脑整合和分离概率 (P_int,P_seg).
- 为了研究这些大脑状态如何随着年龄的增长而变化.
- 为了确定与年龄相关的大脑动态的变化是否与连接强度或网络拓有关.
主要方法:
- 将整合和分离映射到Ising模型的秩序和混乱状态.
- 从功能性MRI (fMRI) 数据中计算的状态概率 (P_int,P_seg).
- 分析了三个独立数据库的变化,并与结构和扩散MRI数据进行了比较.
主要成果:
- 整合 (P_int) 随着年龄的增长显著下降.
- 在所有数据集中,随着年龄的增长,分离 (P_seg) 显著增加.
- 观察到的变化与功能连接强度的减弱相关,而不是结构连接性的改变.
结论:
- 与年龄相关的大脑整合的下降和分离的增加是强有力的发现.
- 这些动态变化主要是由大脑区域之间的连接强度减少所驱动的.
- 这些发现为分析大脑动态及其衰老轨迹提供了一种新的基于物理的方法.
更多相关视频
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
10.1K
11:57Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
Published on: November 26, 2017
8.4K
相关概念视频
Aging
19
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
19
Integration of Synaptic Events
1.3K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability...
1.3K
Neurogenesis and Regeneration of Nervous Tissue
665
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
665
Neuronal Communication
607
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
607
Notch Signaling Pathway
4.1K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.1K
Synaptic Signaling
74.6K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
74.6K
