相关实验视频

Updated: May 7, 2025

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

关于认知障碍中NF-κB的研究热点和趋势:一个参考文献分析

Lin Bai^1,2, Fangyuan Xu², Peijia Hu^1,2

¹The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.

Frontiers in medicine

|December 30, 2024

概括

这项研究分析了对认知障碍 (CI) 中核因子kappa B (NF-κB) 途径的研究. 关键发现突出了神经炎症,并建议未来研究CI的治疗点,微生物群和性饮食.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

认知障碍 (CI) 构成了重大的健康挑战,预测表明受影响个体的数量将大幅增加.
炎症损伤,特别是涉及核因子kappa B (NF-κB) 信号通路,涉及到CI的致病性.
之前没有报道过NF-κB和CI关系的综合文献分析.

研究的目的:

进行关于NF-κB在认知障碍中的作用研究的文献分析.
确定该领域的研究前沿,热点和趋势.
想象NF-κB和CI研究的智力结构和协作格局.

主要方法:

对2008年1月1日至2023年12月12日期间发表的文章进行了参考文献分析,这些文章来自Web of Science核心集合 (科学引用索引扩展).
使用VOSviewer和CiteSpace软件进行数据分析,包括识别作者,国家,机构,关键词和引用网络.
总共分析了1468篇文章 (原始研究和评论).

主要成果:

在CI中NF-κB的研究在2010年出现,从2018年开始,出版物的显著增加.
中国在出版量方面处于领先地位,而美国则表现出显著的影响力和国际合作.
关键的研究主题包括"阿波利波蛋白e"",治疗点"",神经炎症",肠道微生物群和性饮食",神经炎症"和"微质"途径被确定为当前的热点.

结论:

NF-κB在CI中的作用是一个勃发展的研究领域,神经炎症,微质激活和相关途径是目前的焦点.
虽然基础研究占主导地位,但未来的研究应该扩大到探索治疗点,肠道微生物群和基因饮食干预措施.
这种文献计量分析为研究领域提供了宝贵的见解,并为了解NF-κB在认知障碍中的作用提供了未来的方向.

关键词:

在CiteSpace中使用CiteSpace.在 NF-κBB 中.在VOSviewer中使用VOSviewer.文献计量分析的分析认知障碍是一种认知障碍.

更多相关视频

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

Published on: August 17, 2015

相关概念视频

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

Co-activators and Co-repressors

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...