系统性审查:全血细胞计组分节律的差异
Anna Busza1, Vani Sharma2, Kendall Ferguson3
1Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sleep advances : a journal of the Sleep Research Society
|December 30, 2024
概括
完整血清 (CBC) 参考值往往忽略了每天的变化. 这次审查发现CBC成分的每日波动很大,淋巴细胞在一夜之间达到峰值,突出了精准医学需要依赖时间的解释.
科学领域:
- 血液学 血液学 血液学
- 临床病理学 临床病理学
- 时间生物学 时间生物学
背景情况:
- 全血细胞计 (CBC) 是一个具有广泛参考范围的常规诊断测试.
- 目前对CBC值的解释不考虑每天的变化.
- 了解CBC成分的日常节奏对于准确的临床评估至关重要.
研究的目的:
- 系统地审查现有的关于全血细胞计 (CBC) 参数日间变化的文献.
- 为了确定各种CBC组件的高峰和低谷时间.
- 为了告知潜在的CBC结果的时间依赖性解释.
主要方法:
- 在24小时内对至少有三个CBC采集的研究进行系统的文献搜索.
- 选了164篇全文文章,其中32篇被纳入最终分析 (548名患者).
- 使用多项式函数和森林地块分析CBC组件数据的元分析.
主要成果:
- 在多个CBC组件中观察到显著的日间变化.
- 淋巴细胞表现出明显的昼夜节律,夜间 (23:54) 达到峰值,早上 (10:47) 达到低谷.
- 红细胞,血红蛋白和血红素在早上达到峰值;血小板,中性粒细胞,单细胞和基细胞在下午晚些时候达到峰值.
结论:
- 有限的研究描述了CBC组件节律,但存在显著的每日变化,特别是在淋巴细胞.
- 这些发现表明,CBC结果的时间依赖解释有可能存在.
- 未来需要使用更大的数据集进行研究,以支持精准医学方法.
相关概念视频
01:30Pulse rhythm
717
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
717
01:20Regulation of Pulse
1.1K
Pulse regulation involves physiological mechanisms that ensure adequate blood flow throughout the body. The heartbeat, regulated by the autonomic nervous system, is influenced by hormonal balance, physical activity, and emotional state.
1.1K
01:13Special considerations while measuring pulse
539
Assessing a patient's pulse is a fundamental skill in healthcare, but certain situations require special attention:
539
01:28Special considerations while measuring blood pressure
688
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
688
01:11Assessment of radial pulse
738
Assessment of Radial Pulse
The radial pulse, located at the wrist, is often the preferred site for assessing peripheral pulse because of its accessibility and dependability. The process of determining the radial pulse involves several steps:
The radial pulse, located at the wrist, is often the preferred site for assessing peripheral pulse because of its accessibility and dependability. The process of determining the radial pulse involves several steps:
738
01:25Assessment of apical radial pulse
683
Apical-Radial (A-R) Pulse Assessment
The A-R pulse assessment involves simultaneous evaluation of the apical and radial pulses. When the apical and radial pulse rates vary, this assessment helps identify a pulse deficit.
Pre-Procedural Preparation
The A-R pulse assessment involves simultaneous evaluation of the apical and radial pulses. When the apical and radial pulse rates vary, this assessment helps identify a pulse deficit.
Pre-Procedural Preparation
683