暴露于内分泌干扰化学物质和女性生育能力下降:从病理生理学到表观遗传风险
Sophian Tricotteaux-Zarqaoui1,2, Marwa Lahimer1,2, Maria Abou Diwan1,3
1PERITOX-Périnatalité et Risques Toxiques-UMR_I 01 UPJV/INERIS, Centre Universitaire de Recherche en Santé, CURS-UPJV, University of Picardie Jules Verne, CEDEX 1, Amiens, France.
Frontiers in public health
|December 30, 2024
概括
日常产品中的内分泌干扰化学物质 (EDC) 与女性不孕症有关. 本次审查审查了EDCs.
科学领域:
- 生殖毒理学 生殖毒理学
- 环境健康 环境健康
- 内分泌学 在内分泌学.
背景情况:
- 人类不孕症是一个日益严重的公共卫生问题,具有重大的社会和健康影响.
- 内分泌干扰化学物质 (EDC) 越来越多地被认为是不孕症的危险因素.
- 无处不在的EDC暴露发生在常见的产品中,如食品容器,化品和农药.
研究的目的:
- 审查关于生殖障碍与女性暴露于EDCs之间的联系的科学文献.
- 了解特定的EDCs,包括酸盐,双,二氧化和农药,对女性生殖健康的影响.
- 专注于EDCs对女性生殖系统,胚胎发生和相关病理的影响.
主要方法:
- 关于研究内分泌干扰剂和女性生殖健康的综合文献综述.
- 分析研究,重点关注EDCs影响卵细胞成熟,排卵和子宫功能的机制.
- 检查数据,将EDC暴露与子宫内膜异位症,早产卵巢衰竭和胚胎缺陷等疾病联系起来.
主要成果:
- 暴露于EDC与女性内分泌平衡的丧失有关,影响生殖功能.
- 与EDC相关的特定生殖问题包括改变卵细胞成熟和能力,无排卵和子宫疾病.
- EDCs有助于诸如子宫内膜异位症,早产卵巢衰竭 (POI),胚胎缺陷和体外受精 (IVF) 成功率的降低等疾病.
结论:
- EDC对女性生殖健康构成重大威胁,导致一系列疾病.
- 由于使用含有化学物质的产品的比例较高,女性可能更容易暴露于EDC.
- 需要进一步的研究和公共卫生策略来缓解EDC暴露及其生殖后果.
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