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在MASLD中认知障碍与前额叶和感觉皮层中桃体相关的连接功能障碍有关

Yihan Jin^1,2, Ruoyu Tang¹, Liqiang Wu^1,2

¹School of Clinical Medicine, Hangzhou Normal University, 310015 Hangzhou, Zhejiang, China.

Journal of integrative neuroscience

|December 30, 2024

概括

改变的杏仁体功能连接 (FC) 可能作为神经成像标志物用于轻度认知障碍 (MCI) 在代谢功能障碍相关的脂肪性肝病 (MASLD). 内脏脂肪积累可能会使MCI的MASLD患者的脑功能障碍恶化.

科学领域:

神经成像是一种神经成像.
代谢障碍代谢障碍代谢障碍
认知科学认知科学

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 与轻度认知障碍 (MCI) 有关.
杏仁体在代谢功能障碍期间的认知处理中的作用是公认的,但其在MCI (MCI_MASLD) 的MASLD中的具体参与尚不清楚.

研究的目的:

通过检查杏仁体功能连接 (FC) 来研究MCI在MASLD背后的神经机制.
在MASLD患者中识别MCI的潜在神经成像标志物.

主要方法:

休息状态功能磁共振成像 (fMRI) 用于评估74名MASLD患者 (43名MCI_MASLD,31名非MCI_MASLD) 和62名健康对照 (HC) 的FC.
基于种子的FC分析侧重于双边桃体,在三个组之间进行统计比较.
心理量表,肝脏脂肪含量和血液指数也被评估.

主要成果:

与非MCI_MASLD患者相比,MCI_MASLD患者表现出增强的右桃体到中部前额叶皮层 (mPFC) FC和减少的左桃体到左补充运动区域 (SMA) FC.
在mPFC和SMA中的FC与认知分数 (MoCA) 和肝脏脂肪含量相关.
与HC相比,MASLD患者表现出较高的双边杏仁体FC与前额-边缘-半脑电路.

结论:

异常的杏仁体FC模式可以作为MCI在MASLD中的神经成像生物标志物.
这些连接性障碍涉及对认知和感官处理至关重要的大脑区域.
内脏脂肪积累可能导致或加剧MASLD中的大脑功能障碍.

关键词:

阿米格达拉的桃体功能连接性的功能连接性与代谢功能障碍相关的脂肪性肝病.轻度的认知障碍轻度的认知障碍非酒精性脂肪性肝病是非酒精性脂肪性肝病.

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