玻璃眼中的循环节障碍:原因,后果和对策
Denis Gubin1,2,3, Tatyana Malishevskaya4, Dietmar Weinert5
1Department of Biology, Tyumen Medical University, 625023 Tyumen, Russia.
Frontiers in bioscience (Landmark edition)
|December 30, 2024
概括
玻璃眼会损害视网膜细胞,扰乱身体的内部时钟和睡眠模式. 恢复昼夜健康可以通过平衡光照和黑激素来帮助玻璃眼管理.
科学领域:
- 眼科和时间生物学.
- 神经科学和生理学是神经科学和生理学.
背景情况:
- 眼睛,特别是内在光敏感的视网膜质细胞 (ipRGCs),通过上神经核 (SCN) 同步身体的昼夜节律.
- 眼睛内部的局部昼夜节律会影响像光受体灵敏度和眼内流体动力学这样的功能.
研究的目的:
- 为了探索眼和昼夜节律障碍之间的联系.
- 讨论眼睛在昼夜调节中的作用以及青光眼如何影响它.
主要方法:
- 审查现有的关于青光眼的文献,昼夜节律,以及眼睛在光传导中的作用.
- 讨论光学连贯断层扫描 (OCT) 用于评估视网膜质细胞 (RGC) 损伤.
主要成果:
- 由于氧化应激和神经炎症引起的玻璃眼视网膜损伤,破坏了中央和地方的昼夜节律.
- 循环节障碍会对睡眠,情绪和新陈代谢产生负面影响,这可能会对青光眼的进展产生潜在影响.
结论:
- 玻璃眼引起的昼夜干扰需要进一步调查潜在的机制.
- 改善昼夜健康的策略,包括光管理和慢性治疗,可能为玻璃眼治疗提供新的途径.
相关概念视频
Glaucoma: Overview
465
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
465
Open Angle Glaucoma: Treatment
355
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
355
Angle Closure Glaucoma: Treatment
360
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
360
Photoreceptors and Visual Pathways
5.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.4K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
31
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
31
Accessory Structures of the Eye
1.3K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.3K


