青少年的分化甲状腺癌 - - 呈现时疾病的程度是否与年龄不同?
Priya Arya1, Emily A Wright2, Eric K Shaw1
112241 Mercer University School of Medicine , Savannah, GA, USA.
Journal of pediatric endocrinology & metabolism : JPEM
|December 30, 2024
概括
15岁,而不是18岁,可能更好地定义了青少年分化甲状腺癌 (DTC) 的风险. 年轻患者 (<15) 的结节参与度较高,而老年患者 (>15) 的组织结构更具侵入性.
科学领域:
- 内分泌学 在内分泌学.
- 儿科瘤学 儿科瘤学
- 手术瘤学手术瘤学
背景情况:
- 差异化甲状腺癌 (DTC) 管理通常在18岁时从儿科转向成人护理范式.
- 这种过渡的最佳年龄,特别是关于病理风险分层的最佳年龄,仍在争论中.
研究的目的:
- 评估18岁是否是差异化甲状腺癌 (DTC) 护理过渡的明确病理转折点.
- 确定一个替代年龄值是否能更好地区分青少年DTC患者的风险.
主要方法:
- 对153名年龄在12-24岁的患者进行了回顾性图表审查,这些患者在2010-2020年期间接受了DTC手术.
- 对病态瘤 (pT) 和结节 (pN) 阶段的分析,比较年龄组<18与≥18,≤15与≥15.
主要成果:
- 在比较<18岁和≥18岁 (p=0.009) 时,发现年龄和pT阶段之间存在显著关系,但pN阶段 (p=0.319) 却没有.
- 对比患者≤15与>15年显示了pT阶段 (p=0.015) 和pN阶段 (p=0.016) 的显著关系.
- 15岁以下的患者的pT2瘤 (48.9%) 和pN1b疾病 (31.1%) 的发病率较高,而15岁以上的患者的pT1瘤 (37.9%) 和pN0疾病 (33.3%) 的发病率较高.
结论:
- 截止年龄为15岁,而不是18岁,在DTC的节点参与风险中显示出更显著的差异.
- 15岁及以下的患者更容易发生结节转移,而15岁以上的患者则表现出更多侵袭性组织学标志物.
相关概念视频
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:30Skin Cancer
3.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.1K