患者肠道微生物群组成的改变:系统性审查和元分析
Seyede Maryam Mousavi1, Sobhan Younesian1, Hanieh-Sadat Ejtahed2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Microbial pathogenesis
|December 30, 2024
概括
与显著的肠道微生物群变化有关. 虽然整体多样性仍然相似,但像Verrucomicrobia这样的特定细菌增加,而在患者中,Roseburia,Blautia和Dialister减少.
科学领域:
- 神经学 神经学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 越来越多的证据将,一种以为特征的神经系统疾病,与肠道微生物群的改变联系在一起.
- 肠道微生物群失生症越来越被认为是各种神经疾病的潜在因素.
研究的目的:
- 与健康对照人群相比,系统地审查和元分析患者肠道微生物群组成的变化.
- 调查肠道微生物多样性和丰富性的差异.
主要方法:
- 在2024年6月26日之前,对主要科学数据库 (PubMed,Scopus,Web of Science,Embase) 进行了全面的系统搜索.
- 包括16个病例控制研究 (438名患者,369名对照) 和对α和β多样性和细菌相对丰富性的元分析.
- 使用纽卡斯尔-太华尺度 (NOS) 评估研究质量.
主要成果:
- 在患者和对照人群之间,α-多样性没有显著差异.
- 在11项研究中的8项中观察到β-多样性 (微生物群组成) 的显著差异.
- 在患者中发现Verrucomicrobia的增加和Roseburia,Blautia和Dialister属的减少.
结论:
- 与肠道微生物群组成的显著改变有关.
- 与神经炎症相关的特定细菌属在患者中升高.
- 研究结果表明,肠道微生物群的破坏与发症之间存在联系,尽管异质性需要进一步研究.
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