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通过AAV2介导的ABD-FGF21基因传递在2型糖尿病小鼠中产生持续的抗高血糖效应

Sen-Lin Lu1, Zhi-Hao Pan1, Zhi Cui2

  • 1College of Medicine and Health Sciences, China Three Gorges University, Yichang 443002, China; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China.

Life sciences
|December 30, 2024
PubMed
概括

这项研究开发了一种长效的纤维细胞生长因子21 (FGF21) 疗法,使用AAV2基因传递与白蛋白结合域 (ABD) 融合. 在2型糖尿病小鼠模型中,AAV2-ABD-FGF21治疗有效改善了甘油脂代谢和血糖控制.

关键词:
腺相关病毒2型专辑蛋白结合域是一个专辑蛋白结合域.纤维细胞生长因子 212型糖尿病是什么? 2型糖尿病是什么?

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