长期使用南德罗龙酸治疗会减少左心室收缩反应,即使与力量训练相结合,也会减少
Lucas D Ferreira1, Bruno A Aguilar1, João V M Bernal1
1Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Steroids
|December 30, 2024
概括
超生理剂量的纳德罗隆二甲酸会损害心脏功能和表现,即使同时进行力量训练. 力量训练对这些不利的心血管影响提供了最小的保护.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类固醇使用普遍用于表现和美学.
- 类固醇的超生理剂量可能会对生理系统产生负面影响.
- 关于南德罗隆二甲酸对心脏的影响的了解有限,特别是在与力量训练相结合时.
研究的目的:
- 为了研究与力量训练相结合的超生理性纳德罗隆二甲酸剂量对心脏的影响.
- 评估对心脏血液动力学,形态学和功能性参数的影响.
主要方法:
- 雄性Wistar大鼠被分为接受载体治疗 (VEH) 和接受纳德罗隆酸治疗 (NAN) 的两组.
- 每组中的一半接受了为期12周的渐进式力量训练 (T-VEH,T-NAN).
- 使用心声学评估心脏参数,并分析隔离心脏的冠状动脉 perfusion 压力和左心室压力 (LVP).
主要成果:
- 纳德罗隆二甲酸治疗增加了相对心脏质量和左心室尺寸.
- NAN组显示冠状动脉 perfusion 压力,LVP 和收缩率 (dP/dT) 的降低.
- 与对照组相比,力量训练 (T-NAN) 也显示出冠状动脉 perfusion 压力和 LVP 的降低.
结论:
- 超生理性纳德罗隆二甲酸剂量显著损害左心室的性能.
- 力量训练只能在很小程度上减轻南德罗二甲酸诱导的心脏功能障碍.
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