第1组先天性淋巴细胞通过干扰素玛介导途径保护肝脏移植者免受缺血-再输液损伤
Hidenobu Kojima1, Thomas A Morinelli2, Yue Wang2
1The Dumont-UCLA Transplantation Center, Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
概括
天生的淋巴细胞 (ILCs) 保护移植后的肝移植免受伤害. 由ILCs产生的干扰素高调节c-FLIP,防止肝细胞死亡并改善移植结果.
科学领域:
- 免疫学 免疫学 免疫学
- 移植生物学 移植生物学
- 细胞生物学 细胞生物学
背景情况:
- 天生的淋巴细胞 (ILC) 是重要的免疫调节者,但它们在肝移植 (LT) 中的作用尚不清楚.
- 肝脏缺血-反损伤 (IRI) 是 LT 后的一个主要并发症.
研究的目的:
- 为了研究ILCs在肝脏IRI中的作用,在LT之后.
- 阐明ILCs影响LT结果的机制.
主要方法:
- 鼠类的正体模型 LT 模型.
- 基因表达分析 (干扰素玛).
- 抗体介导的细胞枯竭和细胞因子中和/治疗.
- 在c-FLIP表达的体外和体内研究.
- 人肝移植活检分析 (单细胞RNA测序).
主要成果:
- 接受者和捐赠者组1 ILCs保护肝脏移植物免受IRI的影响.
- 由ILCs产生的干扰素玛 (IFN-γ) 在肝细胞中上调c-FLIP表达.
- IFN-γ 保护肝细胞免受炎症性细胞死亡的影响.
- 在人类LT中,较高的c-FLIP水平与较低的IRI和早期的全移植功能障碍相关.
结论:
- 第1组ILCs通过干扰素,在移植期间对肝移植产生细胞保护作用.
- 这种机制涉及c-FLIP的上调,减少炎症细胞死亡,改善移植的生存.
相关概念视频
01:40Cell-mediated Immune Responses
66.9K
Overview
66.9K
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:29Immune Response Against Viral Pathogens
745
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
745
01:28Cells of the Innate Immune Response
1.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.5K