来自四个不同的祖先的I型抗蛋白的融合进化,以应对全球冷却
Laurie A Graham1, Peter L Davies2
1Department of Biomedical and Molecular Sciences, Queen's University, Botterell Hall, 18 Stuart Street, Kingston, K7L 3N6, Canada.
BMC molecular and cell biology
|December 30, 2024
概括
鱼类抗蛋白 (AFP) 独立地进化了多次. 这项研究揭示了鱼和牛鱼AFP的新起源,突出了对冰川事件的反应中的融合进化.
科学领域:
- 进化生物学 进化生物学
- 分子进化分子进化
- 生物化学 生物化学
背景情况:
- 第一种类型的抗蛋白 (AFPs) 是鱼类中发现的富含氨酸的α螺旋蛋白.
- 这些AFP被认为在过去的3000万年里至少四次独立进化.
- 之前的研究证实了鱼和甲鱼AFPs通过基因复制和扩张的独立起源.
研究的目的:
- 研究鱼和牛鱼的抗蛋白 (AFP) 的进化起源.
- 为了确定这些AFP是否通过与以前识别的鱼类AFP类似的机制产生.
- 了解基因重复,分歧和基因组元素在AFP进化中的作用.
主要方法:
- 对产生AFP的鱼及其亲属进行比较基因组分析.
- 检查基因位置,合成和基因拷贝数.
- 在AFP基因区域中对重复性DNA和转位子含量的分析.
主要成果:
- 坎纳AFPs起源于GIMAP基因的重复和分歧,AFP编码区域来自富含氨酸的侧面序列.
- 的AFP基因位点与GIMAPa基因一起扩大,在与相关的鱼物种分离后.
- 牛鱼AFPs是独立进化的,它们的位置以重复的DNA和含有氨酸编码序列的转子体为特征.
结论:
- 鱼和牛鱼AFP的起源代表了独立的进化事件,与鱼类多个AFP起源的假设一致.
- 这些独立的进化发生在北半球中新生代冰期开始后不久.
- 这些发现提供了一个令人信服的例子,即由环境压力驱动的单一蛋白质类型 (I型AFP) 的融合进化.
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