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肺癌患者中性别和术后临床特征之间的关系,这些患者接受了VATS叶切除术
Wei Chen1, Qiangqiang Zheng1, Yi Shen1
1Department of Thoracic Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610044, P.R. China.
Journal of cardiothoracic surgery
|December 30, 2024
概括
接受VATS叶切除术的男性肺癌患者往往呈现出比女性更差的预后因素和更高的并发症率. 根据性别量身定制胸腔排水和外科手术期间的干预措施可以改善结果.
科学领域:
- 胸部外科手术 胸部外科手术
- 手术瘤学手术瘤学
- 肺部病理学 肺部病理学
背景情况:
- 肺癌是全球癌症死亡的主要原因之一.
- 视频辅助胸腔镜外科手术 (VATS) 叶切除术是早期肺癌的标准治疗方法.
- 了解术后特征和结果的性别差异对于优化患者护理至关重要.
研究的目的:
- 为了比较男性和女性肺癌患者的术后临床特征,这些患者接受了VATS叶切除术.
- 调查这些基于性别的差异对短期预后的影响.
主要方法:
- 对338名接受了VATS脑膜切除术的肺癌患者进行了回顾性分析.
- 在男性和女性组之间比较术后的特征和短期结果.
- 多变量二进制物流回归分析以确定风险因素.
主要成果:
- 在年龄,身体表面积,吸烟/饮酒率,高血压,肺功能和临床阶段观察到显著的性别差异.
- 男性患者经历了更长的手术时间和更广泛的淋巴结剖析.
- 在男性中,术后并发症 (肺部感染,空气泄漏,肺气) 和更长的排水/住院时间的发生率更高.
- 在男性中,低FEVI (强迫呼吸量1秒内) 被确定为并发症的独立风险因素.
结论:
- 接受VATS叶切除术的男性肺癌患者往往具有不利因素,如年龄较大,吸烟率较高,肺功能较差和晚期疾病.
- 胸腔排水时间的性别特定调整可能会缩短住院时间.
- 男性患者,特别是肺功能受损的男性患者,需要进行积极的术后干预,以减轻术后并发症的更高风险.
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