在心力衰竭中对身体脆弱性评估的比较与保存的喷射分数
Omar Zainul1, Dylan Marshall1, Jennifer D Lau2
1Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
JACC. Advances
|December 31, 2024
概括
在心力衰竭的脆弱性评估与保存的喷射分数 (HFpEF) 差异很大. 临床虚弱度量表 (CFS),FRAIL量表和5米步行速度测试有效预测HFpEF患者的不良结果.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 临床结果研究研究
背景情况:
- 虚弱性是心力衰竭患者的不良临床结果的重要预测因素,其中包括心力衰竭和保存的喷射分数 (HFpEF).
- 现有的脆弱性评估工具产生了可变的患病率估计和预后价值,需要进行比较分析.
研究的目的:
- 为了比较6种常见的脆弱性评估工具的患病率和预后意义在被诊断为HFpEF的成年人中.
- 为了确定哪些脆弱性措施在预测患者群体内的不良结果方面最有效.
主要方法:
- 分析了203名HFpEF门诊患者的队列.
- 他们比较了六种脆弱性评估:临床脆弱性量表 (CFS),FRAIL量表,5米的步行速度,5次定时的坐立测试,低蛋白血症和修改的体重指数.
- 主要终点是所有原因死亡率和一年内住院的综合结果,使用Cox比例危险模型进行分析.
主要成果:
- 在各个评估中,虚弱的患病率差异很大,从21.2% (低蛋白血症) 到77.8% (定时坐立测试5).
- 在多变量分析中,临床脆弱性量表 (CFS),FRAIL量表和5米步行速度测试与不良结果有显著的关联.
- 脆弱性和不良结果之间的关联随着HFpEF严重程度的提高而增加.
结论:
- 不同的脆弱性评估工具在HFpEF中提供了不同的流行率估计和预后关联.
- CFS,FRAIL尺度和5米步行速度测试显示了与不良结果的显著关联.
- 这三个措施可以作为HFpEF患者常规临床评估的有价值的工具.
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