确定结合普罗波的胺的有效剂量,用于无痛的透视镜检查:一项前性剂量检测研究
Zhimin Sheng1,2, Xiang Liu1, Kang Lin3
1Department of Anesthesiology, Wenling Maternity and Child Healthcare Hospital, Taizhou, China.
Frontiers in pharmacology
|December 31, 2024
概括
对于无痛的透视镜检查,ESKETAMINE与Propofol的最佳剂量是0.429 mg/kg. 这种组合提供了有效的麻醉和止痛,副作用最小,提高了患者在手术过程中的舒适度.
科学领域:
- 麻醉学 麻醉学
- 妇科外科手术 妇科外科
背景情况:
- 乙胺和普罗波通常用于歇斯底里镜术中的静脉全麻醉.
- 这种组合的最佳有效剂量仍未确定.
- 无痛的透视术需要精确的麻醉剂量,以确保患者的安全和程序的成功.
研究的目的:
- 为了确定埃斯基他胺与普罗波福结合的中位有效剂量 (ED50) 和95%有效剂量 (ED95),用于无痛透镜检查.
- 建立一个安全有效的麻醉方案,用于歇斯底里镜手术.
- 为了优化患者的舒适度和在宫镜检查期间的手术结果.
主要方法:
- 用迪克森的上下方法来确定有效剂量.
- 一个初始剂量为0.5毫克/千克埃斯基坦胺,其次是2毫克/千克普罗波.
- 根据患者的反应进行了剂量调整,至少有7次交叉记录.
主要成果:
- 艾斯基坦胺的中位有效剂量 (ED50) 为0.287 mg/kg (95% CI:0.220-0.342).
- 艾斯基坦胺的95%有效剂量 (ED95) 是0.429 mg/kg (95% CI:0.365-0.705).
- 在研究期间没有报告任何严重不良事件.
结论:
- 建议0.429 mg/kg的埃斯基坦胺与普罗波结合剂量用于无痛的透视麻醉.
- 这种剂量增强了麻醉和术后止痛疗效,没有显著的不良反应.
- 临床实践应仔细考虑与此推剂量相关的潜在风险.
相关概念视频
Parenteral Anesthetics: Overview
80
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
80
Local Anesthetics: Clinical Application as Epidural Anesthesia
396
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
396
Depolarizing Blockers: Pharmocokinetics
286
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
286
General Anesthesia: Overview
146
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
146
Stages of General Anesthesia
290
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
290
Local Anesthetics: Common Agents and Their Applications
358
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
358


