AKR1B10和消化系统瘤的发展:一篇综述
Yao Shen1, Ailin Qiu2, Xin Huang3,4
1Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Frontiers in immunology
|December 31, 2024
概括
阿尔多-基因还原酶家族1成员B10 (AKR1B10) 显示为消化系统疾病的生物标志物具有前途. 研究强调其在诊断和治疗各种胃肠道癌症方面的潜力.
科学领域:
- 生物化学 生化学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 阿尔多基因缩酶家族1成员B10 (AKR1B10) 主要是细胞质的,在胃和肠道中表达高.
- 在其他组织中表达低或不存在,使AKR1B10成为消化系统疾病的潜在生物标志物.
研究的目的:
- 在过去5年中,对消化系统瘤中AKR1B10的最新研究进行审查.
- 讨论AKR1B10在瘤和非瘤疾病中的当前趋势和未来研究方向.
主要方法:
- 在过去5年内发表的研究的文献综述.
- 分析AKR1B10表达及其在各种消化系统癌症中的作用.
主要成果:
- AKR1B10与肝细胞癌,胃癌,结肠直肠癌,胰腺癌,口腔状细胞癌,喉状细胞癌,胆管癌和鼻癌有关.
- 最近的研究强调了AKR1B10作为诊断和治疗点的潜力.
结论:
- AKR1B10是消化系统瘤中重要的生物标志物.
- 需要进一步的研究来探索AKR1B10在消化系统的癌症和非癌症疾病中的全部潜力.
更多相关视频
相关概念视频
01:50What is Monogastric Digestion?
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...