病例报告:长期对免疫检查点抑制剂组合作为多种同步癌症单一治疗的长期反应:一个案例研究
Nour Ghammem1, Herve Bischoff1, Pascale Chiappa1
1Medical Oncology, Institut de Cancérologie Strasbourg Europe (ICANS), Strasbourg, France.
Frontiers in immunology
|December 31, 2024
概括
这项案例研究表明,双重免疫检查点抑制剂 (ICI) 疗法有效治疗了一名80岁的男性,患有多种原发性恶性病,包括肝癌,肺癌和脑癌. PD-L1表达是响应的一个关键指标.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症研究 癌症研究
背景情况:
- 免疫检查点抑制剂 (ICI) 通过提高免疫系统对抗瘤的能力,改变了癌症治疗.
- 同步多重原发性恶性瘤 (MPMs) 是一个复杂的治疗挑战,需要新的治疗策略.
研究的目的:
- 报告一个罕见的80岁男性同步MPMs的罕见病例,接受双重ICI治疗.
- 评估双重ICI治疗在患有肝细胞癌,非小细胞肺癌和尿路细胞癌的患者的疗效.
主要方法:
- 该患者接受了针对晚期肝细胞癌和非小细胞肺癌的双重ICI治疗 (杜尔瓦卢马布和特梅利卢马布).
- 使用RECISTv1.1标准来评估治疗反应.
- 随后的尿转移到大脑是通过手术,放射治疗和持续的ICI治疗来管理的.
主要成果:
- 双重ICI治疗在肺部和肝脏病变中取得了部分反应.
- 患者在开始ICI治疗一年后从尿路细胞癌中发展出大脑转移.
- 在治疗大脑转移后,ICI治疗继续进行.
结论:
- 双重ICI疗法在多种同步原发性恶性瘤中显示出有效性.
- PD-L1表达可以作为MPM中ICI反应的预测生物标志物.
- 多学科合作和生物标志物评估对于管理复杂的癌症病例至关重要.
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