社会背景调节了积极的回避:前带皮质在雄性和雌性大鼠的贡献
Shannon Ruble1, Karissa Payne1, Cassandra Kramer1
1Department of Psychological Sciences, Kansas State University, Manhattan, KS, 66506, USA.
Neurobiology of stress
|December 31, 2024
概括
社会背景对积极避免学习产生影响. 在社会环境中的老鼠表现出更多的结和更少的探索,前带皮质 (ACC) 在社会学会的回避中发挥着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 动物行为 动物行为
背景情况:
- 积极避免对生存至关重要.
- 大多数研究都集中在单独避开学习上.
- 社会背景对积极避免的影响还没有得到充分研究.
研究的目的:
- 研究社会背景如何影响大鼠的积极回避学习.
- 在社交和孤独的环境中比较回避行为.
- 检查前带状皮质 (ACC) 在社会学到的回避中所扮演的角色.
主要方法:
- 在老鼠中使用了经过修改的平台介导的回避任务.
- 在社交和单身训练环境中比较避开行为.
- 采用了ACC谷氨酸性神经元的光遗传性失活.
主要成果:
- 与单身环境相比,社会背景增加了条件结,减少了冲刺/寻找食物.
- 避免性差异在孤独的环境中观察到,而不是在社会环境中.
- 当伴侣缺席时,ACC无活化减少了社交环境中的避开行为,但当伴侣在场时却没有.
结论:
- 社会存在调节了积极回避的学习和表达.
- 前带带皮层 (ACC) 参与了在社会背景下学习的回避.
- 这些发现对理解创伤相关疾病和ACC功能障碍有意义.
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