大麻使用与接受免疫检查点抑制剂的固体恶性瘤患者的临床结果之间的关联
Tarik Hadid1,2, Adam Biedny3, Hirva Mamdani4,2
1Department of Oncology, Wayne State University School of Medicine, 540 E Canfield Street, Detroit, MI 48201-1928, USA.
Therapeutic advances in vaccines and immunotherapy
|December 31, 2024
概括
大麻 (CAN) 使用与接受免疫疗法 (IO) 的癌症患者的治疗结果较差有关. 这包括更短的整体存活期 (OS) 和无进展存活期 (PFS),特别是在白人患者中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 大麻 (CAN) 的使用量增加,引发了人们对其对癌症治疗潜在影响的担忧.
- CAN具有免疫抑制特性,可能会干扰免疫疗法 (IO).
- CAN使用对接受IO的癌症患者结局的临床影响尚未得到充分证实.
研究的目的:
- 评估CAN使用对实体瘤患者接受IO的临床影响.
- 在CAN使用者和非使用者之间比较整体生存率 (OS),无进展生存率 (PFS) 和疾病控制率 (DCR).
主要方法:
- 实体恶性瘤患者接受IO的回顾性队列研究 (2014年8月 - 2018年8月).
- 患者被分为CAN用户和非用户.
- 统计分析包括单变量和多变量后勤和考克斯回归.
主要成果:
- 在106名患者中,28%是CAN使用者 (82%使用dronabinol).
- CAN使用者的中位寿命明显差 (6.7个月与17.3个月) 和PFS (4.8个月与9.7个月).
- 疾病控制率 (DCR) 在CAN使用者中较低 (11%对38%),在白人患者中观察到显著的负面影响.
结论:
- 在接受免疫治疗的癌症患者中,大麻使用与劣质的OS,PFS和DCR有关.
- 需要进一步的前性研究来证实这些发现,并调查潜在的种族差异.
- 这项研究表明,在癌症治疗中,CAN和IO之间可能存在对抗性相互作用.
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