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在拉贾斯坦邦的登革热病毒阳性和血清型化趋势

Pratibha Sharma¹, Bharti Malhotra¹, Himanshu Sharma¹

¹Department of Microbiology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.

The Indian journal of medical research

|December 31, 2024

概括

登革热病毒爆发是一个重大的公共卫生问题. 这项研究监测了拉贾斯坦邦的登革热病毒流行率和血清型,在季风后的季节发现成年男性感染率更高.

科学领域:

病毒学病毒学
流行病学流行病学
公共卫生公共卫生

背景情况:

登革热病毒在全球范围内导致频繁,高发病率的疫情.
监测登革热病毒趋势和血清型对于公共卫生至关重要.
拉贾斯坦邦的登革热发病率显著,需要进行当地流行病学研究.

研究的目的:

调查在拉贾斯坦邦的登革热病毒及其血清型的流行情况.
确定该地区登革热感染的人口和季节性模式.
了解八年来流通的登革热血清型.

主要方法:

在拉贾斯坦邦 (2015-2022) 进行了对147,777例临床疑似登革热病例的大规模研究.
使用酶链接免疫吸收试验 (ELISA) 来检测登革热NS1抗原和IgM.
使用聚合酶链反应 (PCR) 来检测病毒RNA和实时PCR用于血型定型.

主要成果:

整体登革热阳性率为19.01% (28,092例). 总体登革热阳性率为19.01% (28,092例). 总体登革热阳性率为19.01% (28,092例). 总体登革热阳性率为19.01% (28,092例).
阳性性峰值发生在季风后的季节,主要影响成年男性 (>15岁).
四种登革热血清型 (DENV-1,DENV-2,DENV-3,DENV-4) 都在流传,最初DENV-2和DENV-3占主导地位,后来转向DENV-1和DENV-2.

结论:

拉贾斯坦邦的登革热感染在季风后和成年男性中最为普遍.
在研究期间,占主导地位的登革热血清型发生了转变,这表明流行病学正在演变.
这些发现有助于理解和管理该地区登革热的变化模式.

关键词:

登革热是因为登革热.在IgM IgM中.在NS1中,NS1是NS1.这是一个PCRPCR.血清类型的确定.病毒病毒病毒病毒

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