成年人周期性吐综合征的症状模式:一个为期6个月的前性观察性研究
Yaozhu J Chen1, Danielle Rodriguez2, Camilla A Richmond1
1Takeda Development Center Americas Inc., Cambridge, Massachusetts, USA.
Neurogastroenterology and motility
|December 31, 2024
概括
周期性吐综合征 (CVS) 情节在持续时间和频率上显示出显著的变化. 这项研究强调了需要更好地描述CVS症状模式和情节的需要.
科学领域:
- 胃肠病学 胃肠病学
- 肠-大脑相互作用障碍 肠-大脑相互作用障碍
背景情况:
- 关于循环吐综合征 (CVS) 的自然史和症状模式的数据有限.
- 简称CVS,是一种肠-大脑相互作用障碍,其特征是反复吐,吐和恶心.
研究的目的:
- 为了前性地评估CVS的成年人的症状模式和自然史.
- 为了描述CVS发作的异质性.
主要方法:
- 使用远程电子日记进行了为期6个月的观察研究.
- 患有CVS的成年患者记录了症状,严重程度和病例细节.
- CVS发作是由特定的每日吐和/或吐事件值来定义的.
主要成果:
- 94.6%的被录取患者提供了可用的日记数据;69.3%的患者至少经历过一次CVS事件.
- 报告的中位数为每30天0.6-0.7次,平均持续时间为2-3天.
- 14.8%的人经历了插曲间的吐/复发,而恶心和腹痛等非吐症状在插曲期间更频繁.
结论:
- 慢性心血管疾病发作在持续时间和相关症状方面表现出明显的异质性.
- 需要进一步的研究来完善CVS发作的定义和特征.
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