产后产妇感染风险在引发分娩后:丹麦国家队列研究
Sidsel Hogh-Poulsen1, Sif Emilie Carlsen1, Jane M Bendix1,2
1Department of Gynecology and Obstetrics, Copenhagen University Hospital-North Zealand, Denmark.
Acta obstetricia et gynecologica Scandinavica
|December 31, 2024
概括
产后诱导使母亲的产后感染风险增加了24%,但绝对风险仍然很低. 诸如子前期和怀孕期间使用抗生素等因素也会增加感染风险.
科学领域:
- 产科和妇科 产科和妇科
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 引产是一种常见的产科手术,丹麦约有25%的阴道分娩是诱导产生的.
- 劳动诱导和产后感染之间的联系,包括子宫内膜炎,手术部位感染,尿路感染和败血症,需要进一步调查.
研究的目的:
- 检查劳动诱导与母亲产后感染风险之间的关联.
- 确定可能导致产后感染的潜在风险因素.
主要方法:
- 一项全国性的队列研究包括了从2007年到2017年的546,864例单独分娩.
- 分娩被分为自发发症,诱导分娩和选择性剖腹产.
- 在30天内产后感染是主要结果,通过诊断代码和抗生素处方确定;用于分析的后勤回归.
主要成果:
- 经过分娩诱导的妇女感染率为8.5%,而自发分娩的感染率为6.8%.
- 诱导分娩与产后感染风险增加有显著的相关性 (调整后OR,1.24;95%CI,1.21-1.27).
- 感染的危险因素包括怀孕期间的抗生素治疗,妊娠前和更长的教育;低/高BMI和以前的分娩与降低风险有关.
结论:
- 产后诱导与母亲产后感染的风险更高有关,尽管绝对增加很小 (1.7%).
- 膜破裂没有提高诱导后的感染风险,BMI显示与感染风险的反向关系.
- 研究结果表明,虽然诱导会增加风险,但绝对风险不是一个主要问题,临床管理可能会影响结果.
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