在接受选择性结直肠手术的老年患者中进行脆弱性查:对七种查仪器进行比较研究
Katleen Fagard1,2, Lisa Geyskens2,3, Björk Van den Bogaert1
1Department of Geriatric Medicine, University Hospital Leuven, Leuven, Belgium.
这项研究比较了七种脆弱性查仪器,用于预测接受结直肠手术的老年人手术后不良结果. 没有单一的仪器显示出优越的诊断准确性,这表明需要多步骤的方法.
科学领域:
- 老年人手术是一门老年手术.
- 手术结果研究研究.
- 脆弱性评估 脆弱性评估
背景情况:
- 脆弱性查对于预测老年手术患者的不良术后结果至关重要.
- 缺乏对不同脆弱查仪器的诊断准确性的比较研究.
- 这项研究解决了为这一群体确定最有效的脆弱查工具的需求.
研究的目的:
- 为了比较七种脆弱查仪器的诊断准确度.
- 评估它们在接受结直肠手术的70岁及以上患者中预测不良术后结果的能力.
主要方法:
- 一项前性队列研究,涉及172名年龄≥70岁的接受结直肠手术的患者.
- 评估了七种脆弱性查仪器:弗莱德和罗宾逊标准,埃德蒙顿脆弱性尺度,洛克伍德临床脆弱性尺度,修改的脆弱性指数,FRAIL问卷和老年8.
- 主要结局:术后并发症与Clavien-Dindo (CD) 严重程度等级≥2;次要结局包括CD≥3并发症,停留时间长,护理水平提高和功能下降.
主要成果:
- 积极的脆弱性查率差异很大 (13.4%73.8%).
- 大多数仪器显示高特异性,但对CD≥2并发症的敏感性较低;老年人8显示更高的敏感性,但特异性较低.
- 所有仪器的整体诊断准确度均为中等 (AUC ≤ 0.61),在改变切断值后没有显著改善.
结论:
- 当前的脆弱性查仪器,当单独使用时,对于该队列的不良术后结果的预测价值有限.
- 一个单一步的脆弱性查不足以准确预测风险.
- 未来的研究应该探索一个两步的方法,包括全面的老年病评估,以改善预测模型.
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