在双相情感障碍中重新配置大脑网络动态:隐藏的马尔科夫模型方法
Xi Zhang1, Lan Yang1, Jiayu Lu1
1School of Computer Science and Technology (School of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China.
Translational psychiatry
|December 31, 2024
概括
双极性障碍 (BD) 患者表现出大脑网络动态的改变,与对照人群相比,他们在超连接状态中花费的时间更少,在反相关状态中花费的时间更长. 这些变化可能与前额叶和顶额叶的结构性破坏有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 双极性障碍 (BD) 涉及显著的情绪波动.
- 动态功能连接 (dFC) 提供了对 BD 情绪和认知过程演变的洞察力.
- 之前的dFC研究经常使用较长的时间尺度,缺少暂时的大脑活动变化.
研究的目的:
- 通过使用隐藏的马尔科夫模型 (HMM) 分析来调查 BD 中的瞬间到瞬间的大脑活动模式.
- 为了评估BD患者改变的全脑网络动态.
- 探索大脑网络功能障碍和BD中的结构变化之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 数据来自43名BD患者和51名对照组.
- 隐藏马尔科夫模型 (HMM) 分析以识别时间大脑状态.
- 脊柱回归 (RR) 为了将大脑动态与结构性破坏相关联.
主要成果:
- 患有BD的患者在超连接状态中花费的时间更少 (效率更高,隔离更低).
- 患有BD的患者在反相关状态中表现出更长的时间,特别是在DMN/SMN,DMN/ION,SCN/SMN和SCN/ION网络之间.
- 认知控制网络的低活化与BD的正面和顶层结构破坏相关.
结论:
- BD的特点是明显的动态大脑网络变化.
- 大脑连接模式的短暂变化对于理解BD至关重要.
- 在BD中改变的大脑动态可能与潜在的结构异常有关,这为研究提供了新的途径.
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